Functional and directed connectivity of the cortico-limbic network in mice in vivo.

ABSTRACT: Higher cognitive processes and emotional regulation depend on densely interconnected telencephalic and limbic areas. Central structures of this cortico-limbic network are ventral hippocampus (vHC), medial prefrontal cortex (PFC), basolateral amygdala (BLA) and nucleus accumbens (NAC). Human and animal studies have revealed both anatomical and functional alterations in specific connections of this network in several psychiatric disorders. However, it is often not clear whether functional alterations within these densely interconnected brain areas are caused by modifications in the direct pathways, or alternatively through indirect interactions. We performed multi-site extracellular recordings of spontaneous activity in three different brain regions to study the functional connectivity in th

SUBMITTER: Khastkhodaei Z 

PROVIDER: S-EPMC7981333 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature