NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling.

ABSTRACT: This is the first report of a NACC2-NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profiling in cancer care.

SUBMITTER: Britton HM 

PROVIDER: S-EPMC7981675 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature