Linked patterns of biological and environmental covariation with brain structure in adolescence: a population-based longitudinal study.

ABSTRACT: Adolescence is a period of major brain reorganization shaped by biologically timed and by environmental factors. We sought to discover linked patterns of covariation between brain structural development and a wide array of these factors by leveraging data from the IMAGEN study, a longitudinal population-based cohort of adolescents. Brain structural measures and a comprehensive array of non-imaging features (relating to demographic, anthropometric, and psychosocial characteristics) were available on 1476 IMAGEN participants aged 14 years and from a subsample reassessed at age 19 years (n = 714). We applied sparse canonical correlation analyses (sCCA) to the cross-sectional and longitudinal data to extract modes with maximum covariation between neuroimaging and non-imaging measures. Separate

SUBMITTER: Modabbernia A 

PROVIDER: S-EPMC7981783 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature