Human placental mesenchymal stem cells ameliorate chemotherapy-induced damage in the testis by reducing apoptosis/oxidative stress and promoting autophagy.

ABSTRACT:

Background

The side effects of busulfan on male reproduction are serious, so fertility preservation in children undergoing busulfan treatment is a major worldwide concern. Human placental mesenchymal stem cells (hPMSCs) have advantages such as stable proliferation and lower immunogenicity that make them an ideal material for stimulating tissue repair, especially restoring spermatogenesis. The protective effects of hPMSCs in busulfan-induced Sertoli cells and in busulfan-treated mouse testes have not been determined. Our study aimed to elaborate the protective effect and potential mechanisms of hPMSCs in busulfan-treated testes and Sertoli cells.

Methods

First, we developed a mouse model of busulfan-induced testicular toxicity in vivo and a mouse Sertoli cell line treated wit

SUBMITTER: Lu J 

PROVIDER: S-EPMC7981860 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature