Cobalt-containing calcium phosphate induces resorption of biomineralized collagen by human osteoclasts.

ABSTRACT:

Background

Biomineralized collagen, consisting of fibrillar type-I collagen with embedded hydroxyapatite mineral, is a bone-mimicking material with potential application as a bone graft substitute. Despite the chemical and structural similarity with bone extracellular matrix, no evidence exists so far that biomineralized collagen can be resorbed by osteoclasts. The aim of the current study was to induce resorption of biomineralized collagen by osteoclasts by a two-fold modification: increasing the calcium phosphate content and introducing cobalt ions (Co²⁺), which have been previously shown to stimulate resorptive activity of osteoclasts.

Methods

To this end, we produced biomineralized collagen membranes and coated them with a cobalt-containing calcium phosphate (

SUBMITTER: de Melo Pereira D 

PROVIDER: S-EPMC7981861 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature