Epigenetic evidence of an Ac/Dc axis by VPA and SAHA.

ABSTRACT:

Background

Valproic acid (VPA) is one of the most commonly used anti-epileptic drugs with pharmacological actions on GABA and blocking voltage-gated ion channels. VPA also inhibits histone deacetylase (HDAC) activity. Suberoylanilide hydroxamic acid is also a member of a larger class of compounds that inhibit HDACs. At the time of this article, there are 123 active international clinical trials for VPA (also known as valproate, convulex, divalproex, and depakote) and SAHA (vorinostat, zolinza). While it is well known that VPA and SAHA influence the accumulation of acetylated lysine residues on histones, their true epigenetic complexity remains poorly understood.

Results

Primary human cells were exposed to VPA and SAHA to understand the extent of histone acetylation (H3K9/14a

SUBMITTER: Lunke S 

PROVIDER: S-EPMC7981901 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature