SVExpress: identifying gene features altered recurrently in expression with nearby structural variant breakpoints.

ABSTRACT:

Background

Combined whole-genome sequencing (WGS) and RNA sequencing of cancers offer the opportunity to identify genes with altered expression due to genomic rearrangements. Somatic structural variants (SVs), as identified by WGS, can involve altered gene cis-regulation, gene fusions, copy number alterations, or gene disruption. The absence of computational tools to streamline integrative analysis steps may represent a barrier in identifying genes recurrently altered by genomic rearrangement.

Results

Here, we introduce SVExpress, a set of tools for carrying out integrative analysis of SV and gene expression data. SVExpress enables systematic cataloging of genes that consistently show increased or decreased expression in conjunction with the presence of nearby SV breakpoints

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7981925 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature