Systematic review: the bioavailability of orally administered antibiotics during the initial phase of a systemic infection in non-ICU patients.

ABSTRACT:

Background

The systemic response to an infection might influence the pharmacokinetics of antibiotics. To evaluate the desired possibility of an earlier (< 24 h) IV-to-oral switch therapy in febrile non-ICU, hospitalized patients, a systematic review was performed to assess the effect of the initial phase of a systemic infection on the bioavailability of orally administered antibiotics in such patients.

Methods

An electronic search was conducted in MEDLINE and Embase up to July 2020. Studies were selected when outcome data were collected during the initial stage of a febrile disease. Outcome data were (maximum) serum concentrations, time of achieving maximum serum concentration, and the area-under-the-plasma-concentration-time curve or bioavailability of orally administered a

SUBMITTER: van den Broek AK 

PROVIDER: S-EPMC7981967 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature