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An insight into osteoarthritis susceptibility: Integration of immunological and genetic background.


ABSTRACT: Osteoarthritis (OA) is a progressive degenerative disease that affects all synovial joints, causing the disability of the main locomotor diarthrodial joints. OA pathogenesis is caused by a complex interplay between a number of genetic and environmental risk factors, involved in the early onset and progression of this chronic inflammatory joint disease. Uncovering the underlying immunological and genetic mechanisms will enable an insight into OA pathophysiology and lead to novel and integrative approaches in the treatment of OA patients, together with a reduction of the disease risk, or a delay of its onset in susceptible patients.

SUBMITTER: Stefik D 

PROVIDER: S-EPMC7982064 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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An insight into osteoarthritis susceptibility: Integration of immunological and genetic background.

Stefik Debora D   Vranic Vladimir V   Ivkovic Nemanja N   Abazovic Dzihan D   Maric Dusan D   Vojvodic Danilo D   Supic Gordana G  

Bosnian journal of basic medical sciences 20210401 2


Osteoarthritis (OA) is a progressive degenerative disease that affects all synovial joints, causing the disability of the main locomotor diarthrodial joints. OA pathogenesis is caused by a complex interplay between a number of genetic and environmental risk factors, involved in the early onset and progression of this chronic inflammatory joint disease. Uncovering the underlying immunological and genetic mechanisms will enable an insight into OA pathophysiology and lead to novel and integrative a  ...[more]

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