Lipidome signatures of metastasis in a transgenic mouse model of sonic hedgehog medulloblastoma.

ABSTRACT: Medulloblastoma (MB), the most common malignant pediatric brain tumor, has high propensity to metastasize. Currently, the standard treatment for MB patients includes radiation therapy administered to the entire brain and spine for the purpose of treating or preventing against metastasis. Due to this aggressive treatment, the majority of long-term survivors will be left with permanent and debilitating neurocognitive impairment, for the 30-40% patients that fail to respond to treatment, all will relapse with terminal metastatic disease. An understanding of the underlying biology that drives MB metastasis is lacking, and is critically needed in order to develop targeted therapeutics for its prevention. To examine the metastatic biology of sonic hedgehog (SHH) MB, the human MB subgroup with th

SUBMITTER: Huang D 

PROVIDER: S-EPMC7982123 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature