Degradation of lymphatic anatomy and function in early venous insufficiency.

ABSTRACT:

Objective

We used near-infrared fluorescence lymphatic imaging in a pilot study to assess the lymphatics in preulcerative (C2-C4) venous insufficiency and determine whether involvement and/or degradation of lymphatic anatomy or function could play a role in the progression of chronic venous insufficiency. We also explored the role of lymphatics in early peripheral arterial disease.

Methods

After informed consent and intradermal injections of indocyanine green for rapid lymphatic uptake, near-infrared fluorescence lymphatic imaging was used to assess the lymphatic anatomic structure and quantify the lymphatic propulsion rates in subjects with early venous insufficiency. The anatomic observations included interstitial backflow, characterized by the abnormal spreading of indocy

SUBMITTER: Rasmussen JC 

PROVIDER: S-EPMC7982349 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature