Autophagy Mediates Leptin-Induced Migration and ERK Activation in Breast Cancer Cells.

ABSTRACT: Autophagy is an intracellular recycling process active in eukaryotic cells that involves the formation of an autophagosome which delivers cytoplasmic components to the lysosome for degradation. This process occurs at low rates under basal conditions, but it can be induced by diverse types of stress such as starvation, hypoxia, metabolic disorders or in response to hormones, including leptin. Leptin is considered a pro-tumorigenic protein whose circulating levels have been related to bad prognosis in obese breast cancer patients. It has been recently demonstrated that leptin can induce autophagy in cancer cell lines from different tissues, suggesting that autophagy could modulate the pro-tumorigenic effects associated with leptin. In this study, the role of autophagy in leptin-induced proli

SUBMITTER: Garcia-Miranda A 

PROVIDER: S-EPMC7982408 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature