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Differential Signals From TNFα-Treated and Untreated Embryos in Uterine Tissues and Splenic CD4⁺ T Lymphocytes During Preimplantation Pregnancy in Mice.

ABSTRACT: The main aim of this study was to examine if a female mouse body in preimplantation pregnancy can distinguish between embryos of normal and impaired biological quality in the local and peripheral compartments. Normal (control group) and TNFα (tumor necrosis factor-α)-treated embryos (experimental group) at the morula stage were non-surgically transferred into the uteri of CD-1 strain [Crl:CD1(Icr)] female murine recipients. Twenty-four hours after the embryo transfer, females were euthanised, and uteri and spleens were dissected. In uterine tissues (local compartment), we assessed the expression of 84 genes comprising nine signal transduction pathways, using a modified RT² Profiler PCR Array. In the spleen (peripheral compartment), we determined the proteome of splenic CD4⁺

SUBMITTER: Buska-Mach K

PROVIDER: S-EPMC7982469 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Dataset Information

Differential Signals From TNFα-Treated and Untreated Embryos in Uterine Tissues and Splenic CD4⁺ T Lymphocytes During Preimplantation Pregnancy in Mice.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Differential Signals From TNFα-Treated and Untreated Embryos in Uterine Tissues and Splenic CD4+ T Lymphocytes During Preimplantation Pregnancy in Mice.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Differential Signals From TNFα-Treated and Untreated Embryos in Uterine Tissues and Splenic CD4⁺ T Lymphocytes During Preimplantation Pregnancy in Mice.