Simplified Dosing Regimens for Gentamicin in Neonatal Sepsis.

ABSTRACT: Background: The effectiveness of antibiotics for the treatment of severe bacterial infections in newborns in resource-limited settings has been determined by empirical evidence. However, such an approach does not warrant optimal exposure to antibiotic agents, which are known to show different disposition characteristics in this population. Here we evaluate the rationale for a simplified regimen of gentamicin taking into account the effect of body size and organ maturation on pharmacokinetics. The analysis is supported by efficacy data from a series of clinical trials in this population. Methods: A previously published pharmacokinetic model was used to simulate gentamicin concentration vs. time profiles in a virtual cohort of neonates. Model predictive performance was assessed

SUBMITTER: D'Agate S 

PROVIDER: S-EPMC7982486 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature