Harmful Effects of Granulocytic Myeloid-Derived Suppressor Cells on Tuberculosis Caused by Hypervirulent Mycobacteria.

ABSTRACT:

Background

The role of myeloid-derived suppressor cells (MDSCs) in patients with severe tuberculosis who suffer from uncontrolled pulmonary inflammation caused by hypervirulent mycobacterial infection remains unclear.

Methods

This issue was addressed using C57BL/6 mice infected with highly virulent Mycobacterium bovis strain MP287/03.

Results

CD11b+GR1int population increased in the bone marrow, blood and lungs during advanced disease. Pulmonary CD11b+GR1int (Ly6GintLy6Cint) cells showed granularity similar to neutrophils and expressed immature myeloid cell markers. These immature neutrophils harbored intracellular bacilli and were preferentially located in the alveoli. T-cell suppression occurred concomitantly with CD11b+GR1int cell accumulation in the lungs. Further

SUBMITTER: Barbosa Bomfim CC 

PROVIDER: S-EPMC7982567 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature