Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer's Disease.

ABSTRACT: Selenium (Se) and its compounds have been reported to have great potential in the prevention and treatment of Alzheimer's disease (AD). However, little is known about the functional mechanism of Se in these processes, limiting its further clinical application. Se exerts its biological functions mainly through selenoproteins, which play vital roles in maintaining optimal brain function. Therefore, selenoproteins, especially brain function-associated selenoproteins, may be involved in the pathogenesis of AD. Here, we analyze the expression and distribution of 25 selenoproteins in the brain and summarize the relationships between selenoproteins and brain function by reviewing recent literature and information contained in relevant databases to identify selenoproteins (GPX4, SELENOP, SELENOK,

SUBMITTER: Zhang ZH 

PROVIDER: S-EPMC7982578 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature