Association of image-defined risk factors with clinical features, histopathology, and outcomes in neuroblastoma.

ABSTRACT:

Background

Clinical, molecular, and histopathologic features guide treatment for neuroblastoma, but obtaining tumor tissue may cause complications and is subject to sampling error due to tumor heterogeneity. We hypothesized that image-defined risk factors (IDRFs) would reflect molecular features, histopathology, and clinical outcomes in neuroblastoma.

Methods

We performed a retrospective cohort study of 76 patients with neuroblastoma or ganglioneuroblastoma. Diagnostic CT scans were reviewed for 20 IDRFs, which were consolidated into five IDRF groups (involvement of multiple body compartments, vascular encasement, tumor infiltration of adjacent organs/structures, airway compression, or intraspinal extension). IDRF groups were analyzed for association with clinical, molecular

SUBMITTER: Temple WC 

PROVIDER: S-EPMC7982630 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature