Serological surveillance of SARS-CoV-2: Six-month trends and antibody response in a cohort of public health workers.

ABSTRACT:

Background

Antibody waning after SARS-CoV-2 infection may result in reduction in long-term immunity following natural infection and vaccination, and is therefore a major public health issue. We undertook prospective serosurveillance in a large cohort of healthy adults from the start of the epidemic in England.

Methods

Clinical and non-clinical healthcare workers were recruited across three English regions and tested monthly from March to November 2020 for SARS-CoV-2 spike (S) protein and nucleoprotein (N) antibodies using five different immunoassays. In positive individuals, antibody responses and long-term trends were modelled using mixed effects regression.

Findings

In total, 2246 individuals attended 12,247 visits and 264 were seropositive in ≥ 2 assays. Most seroc

SUBMITTER: Harris RJ 

PROVIDER: S-EPMC7982645 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature