Meta-Analysis: Association Between Hypoglycemia and Serious Adverse Events in Older Patients Treated With Glucose-Lowering Agents.

ABSTRACT:

Aims

We conducted a meta-analysis of serious adverse events (dementia, macro- and micro-vascular events, falls and fractures, and death) associated with hypoglycemia in older patients treated with glucose lowering drugs.

Materials and methods

Meta-analysis of studies reporting on hypoglycemia and adverse events. The search included studies from two previously published systematic reviews, and an updated search of MEDLINE and EMBASE from April 2014 to November 2019. We assessed study validity based on ascertainment of hypoglycemia, adverse events and adjustment for confounders, and conducted a random effects meta-analyses, assessing heterogeneity using the I² statistic.

Results

We included 44 studies involving 2,507,434 participants. Most of the studies used

SUBMITTER: Mattishent K 

PROVIDER: S-EPMC7982741 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature