MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19.

ABSTRACT: Components of the complement system and atypical parameters of coagulation were reported in COVID-19 patients, as well as the exacerbation of the inflammation and coagulation activity. Mannose binding lectin (MBL)- associated serine proteases (MASPs) play an important role in viral recognition and subsequent activation of the lectin pathway of the complement system and blood coagulation, connecting both processes. Genetic variants of MASP1 and MASP2 genes are further associated with different levels and functional efficiency of their encoded proteins, modulating susceptibility and severity to diseases. Our review highlights the possible role of MASPs in SARS-COV-2 binding and activation of the lectin pathway and blood coagulation cascades, as well as their associations with comorbidities o

SUBMITTER: Bumiller-Bini V 

PROVIDER: S-EPMC7982787 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature