Mechanistic Drivers of Mullerian Duct Development and Differentiation Into the Oviduct.

ABSTRACT: The conduits of life; the animal oviducts and human fallopian tubes are of paramount importance for reproduction in amniotes. They connect the ovary with the uterus and are essential for fertility. They provide the appropriate environment for gamete maintenance, fertilization and preimplantation embryonic development. However, serious pathologies, such as ectopic pregnancy, malignancy and severe infections, occur in the oviducts. They can have drastic effects on fertility, and some are life-threatening. Despite the crucial importance of the oviducts in life, relatively little is known about the molecular drivers underpinning the embryonic development of their precursor structures, the Müllerian ducts, and their successive differentiation and maturation. The Müllerian ducts are simple rudim

SUBMITTER: Santana Gonzalez L 

PROVIDER: S-EPMC7982813 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature