Patterns and Treatment Strategies of Osimertinib Resistance in T790M-Positive Non-Small Cell Lung Cancer: A Pooled Analysis.

ABSTRACT:

Introduction

Osimertinib resistance is inevitable. The purpose of this study was to explore the predictive value of pretreatment clinical characteristics in T790M-positive non-small cell lung cancer NSCLC patients for the resistance pattern of osimertinib during tumor progression as well as the treatment strategy.

Methods

We performed a literature search in the NCBI PubMed database to identify relevant articles and completed a pooled analysis based on 29 related published studies. The relationship between clinical characteristics, EGFR mutation type, previous treatment history and the gene mutation pattern at resistance to osimertinib was analyzed.

Results

A total of 38 patients were included in the pooled analysis. Patients with an initial epidermal growth factor rec

SUBMITTER: Wang C 

PROVIDER: S-EPMC7982860 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature