Proteomic changes in intracranial blood during human ischemic stroke.

ABSTRACT:

Background

Since 2015, mechanical thrombectomy has been the standard treatment for emergent large vessel occlusion ischemic stroke.

Objective

To investigate, using the previously published Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC) protocol (clinicaltrials.gov NCT03153683), how the protein expression of a patient's intracranial blood during ischemic stroke compares with the protein expression of their systemic arterial blood in order to better understand and treat stroke.

Methods

Plasma samples from 25 subjects underwent proteomic analysis, where intracranial protein expression was compared with systemic protein levels. Data including sex, comorbidities, infarct volume, and infarct time were included for each subject.

Results

A majority of

SUBMITTER: Maglinger B 

PROVIDER: S-EPMC7982920 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature