Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population.

ABSTRACT: Clinical conditions correlated with elevated triglyceride levels are well-known: coronary heart disease, hypertension, and diabetes. Underlying genetic and phenotypic mechanisms are not fully understood, partially due to lack of coordinated genotypic-phenotypic data. Here we use a subset of the Healthy Nevada Project, a population of 9,183 sequenced participants with longitudinal electronic health records to examine consequences of altered triglyceride levels. Specifically, Healthy Nevada Project participants sequenced by the Helix Exome+ platform were cross-referenced to their electronic medical records to identify: (1) rare and common single-variant genome-wide associations; (2) gene-based associations using a Sequence Kernel Association Test; (3) phenome-wide associations with triglycer

SUBMITTER: Read RW 

PROVIDER: S-EPMC7982958 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature