Calculation of Stop Ages for Colorectal Cancer Screening Based on Comorbidities and Screening History.

ABSTRACT:

Background & aims

Routine screening for colorectal cancer typically is recommended until age 74 years. Although it has been proposed that a screening stop age could be determined based on sex and comorbidity, less is known about the impact of screening history. We investigated the effects of screening history on the selection of an optimal age to stop screening.

Methods

We used the Microsimulation Screening Analysis-Colon model to estimate the harms and benefits of screening with biennial fecal immunochemical tests by sex, comorbidity status, and screening history. The optimal screening stop age was determined based on the incremental number needed for 1 additional life-year per 1000 screened individuals compared with the threshold provided by stopping screening at 76 years

SUBMITTER: Cenin DR 

PROVIDER: S-EPMC7982961 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature