Class switching and high-affinity immunoglobulin G production by B cells is dispensable for the development of hypertension in mice.

ABSTRACT:

Aims

Elevated serum immunoglobulins have been associated with experimental and human hypertension for decades but whether immunoglobulins and B cells play a causal role in hypertension pathology is unclear. In this study, we sought to determine the role of B cells and high-affinity class-switched immunoglobulins on hypertension and hypertensive end-organ damage to determine if they might represent viable therapeutic targets for this disease.

Methods and results

We purified serum immunoglobulin G (IgG) from mice exposed to vehicle or angiotensin (Ang) II to induce hypertension and adoptively transferred these to wild type (WT) recipient mice receiving a subpressor dose of Ang II. We found that transfer of IgG from hypertensive animals does not affect blood pressure, endotheli

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7983008 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature