Metabolomic signatures of lead exposure in the VA Normative Aging Study.

ABSTRACT:

Background

Lead (Pb) is widespread and exposure to this non-essential heavy metal can cause multiple negative health effects; however the mechanisms underlying these effects remain incompletely understood.

Objectives

To identify plasma metabolomic signatures of Pb exposure, as measured in blood and toenails.

Methods

In a subset of men from the VA Normative Aging Study, mass-spectrometry based plasma metabolomic profiling was performed. Pb levels were measured in blood samples and toenail clippings collected concurrently. Multivariable linear regression models, smoothing splines and Pathway analyses were employed to identify metabolites associated with Pb exposure.

Results

In 399 men, 858 metabolites were measured and passed QC, of which 154 (17.9%) were signifi

SUBMITTER: Kelly RS 

PROVIDER: S-EPMC7983049 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature