Cerebral perfusion is associated with blast exposure in military personnel without moderate or severe TBI.

ABSTRACT: Due to the use of improvised explosive devices, blast exposure and mild traumatic brain injury (mTBI) have become hallmark injuries of the Iraq and Afghanistan wars. Although the mechanisms of the effects of blast on human neurobiology remain active areas of investigation, research suggests that the cerebrovasculature may be particularly vulnerable to blast via molecular processes that impact cerebral blood flow. Given that recent work suggests that blast exposure, even without a subsequent TBI, may have negative consequences on brain structure and function, the current study sought to further understand the effects of blast exposure on perfusion. One hundred and eighty military personnel underwent pseudo-continuous arterial spin labeling (pCASL) imaging and completed diagnostic and clinic

SUBMITTER: Sullivan DR 

PROVIDER: S-EPMC7983507 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature