Therapeutic Plasma Exchange in Refractory Hyperthyroidism.

ABSTRACT:

Introduction

Hyperthyroid patients who are unresponsive to medical treatment remain a challenging clinical problem.

Objective

The goal of our study was to evaluate the use of therapeutic plasma exchange (TPE) in hyperthyroid patients and their outcome after TPE.

Method

We retrospectively reviewed 22 patients who underwent TPE for refractory thyrotoxicosis in our institution: 13 with Graves' disease, 7 with amiodarone-induced thyrotoxicosis (AIT), 1 with toxic goiter, and 1 pregnant patient with familial nonautoimmune thyrotoxicosis.

Results

Before TPE, all patients had severe hyperthyroidism, and antithyroid drugs were either contraindicated or not sufficiently effective to restore euthyroidism promptly. After all the TPEs, free T₄ (fT4) decreased si

SUBMITTER: Saie C 

PROVIDER: S-EPMC7983568 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature