Promoter Methylation of LEP and LEPR before and after Bariatric Surgery: A Cross-Sectional Study.

ABSTRACT:

Introduction

DNA methylation constitutes one important epigenetic mechanism that regulates gene expression in human cells. With regard to obesity, bariatric surgery-induced weight loss has been associated with promoter methylation changes in several genes. Hyperleptinemia is a characteristic feature of obesity. The underlying regulating mechanisms have not yet been completely elucidated.

Methods

We investigated the methylation of the promoters of the leptin gene (LEP) and the leptin receptor gene (LEPR) as well as leptin expression in pre- and postbariatric surgery patients using a comparative cross-sectional design.

Results

Our results revealed significantly higher LEP promoter methylation patterns in prebariatric surgery patients compared to postoperatively. DNA met

SUBMITTER: Wilhelm J 

PROVIDER: S-EPMC7983678 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature