Neural Connectivity Subtypes Predict Discrete Attentional Bias Profiles Among Heterogeneous Anxiety Patients.

ABSTRACT: On average, anxious patients show altered attention to threat-including early vigilance towards threat and later avoidance of threat-accompanied by altered functional connectivity across brain regions. However, substantial heterogeneity within clinical, neural, and attentional features of anxiety is overlooked in typical group-level comparisons. We used a well-validated method for data-driven parsing of neural connectivity to reveal connectivity-based subgroups among 60 adults with transdiagnostic anxiety. Subgroups were externally compared on attentional patterns derived from independent behavioral measures. Two subgroups emerged. Subgroup A (68% of patients) showed stronger executive network influences on sensory processing regions and a paradigmatic "vigilance-avoidance" pattern on exte

SUBMITTER: Price RB 

PROVIDER: S-EPMC7983837 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature