Effect of varenicline directly observed therapy versus varenicline self-administered therapy on varenicline adherence and smoking cessation in methadone-maintained smokers: a randomized controlled trial.

ABSTRACT:

Background and aims

Level of adherence to tobacco cessation medication regimens is believed to be causally related to medication effectiveness. This study aimed to evaluate the efficacy of varenicline directly observed therapy (DOT) on varenicline adherence and smoking cessation rates among smokers with opioid use disorder (OUD) receiving methadone treatment.

Design

Multicenter, parallel-group two-arm randomized controlled trial.

Setting

Urban opioid treatment program (OTP) in the Bronx, New York, USA.

Participants

Daily smokers of ≥ 5 cigarettes/day, interested in quitting (ladder of change score 6-8), in methadone treatment for ≥ 3 months, attending OTP ≥ 3 days/week. Participants' mean age was 49 years, 56% were male, 44% Latino, 30% Black, and they smoked a

SUBMITTER: Nahvi S 

PROVIDER: S-EPMC7983847 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature