Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model.

ABSTRACT:

Background and aim

The incidence of non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is progressively increasing. However, the pathophysiology and etiology of NASH progression to HCC are unknown. We hypothesized that steatosis was the key factor in NASH-related hepatocarcinogenesis and aimed to evaluate the effects of long-term liver X receptor (LXR) agonist stimulation on hepatic steatosis induced by a high-fat diet and oxidative stress.

Methods

We used an LXR agonist (T0901317) and CCl₄ to induce hepatic steatosis and oxidative stress, respectively. C57BL/6 mice fed with a high-fat diet were treated with either T0901317 + CCl₄ (T09 + CCl₄ group) or CCl₄ alone (CCl₄ group). T0901317 (2.5 mg/kg

SUBMITTER: Shimizu Y 

PROVIDER: S-EPMC7983938 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature