Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough.

ABSTRACT: Chronic cough, defined as a cough lasting > 8 weeks, is a common medical condition that exerts a substantial physical, mental, and social burden on patients. A subset of patients with chronic cough are troubled with a cough that persists despite optimal treatment of presumed associated common and uncommon conditions (refractory chronic cough; RCC) or in which no diagnosable cause for cough can be identified despite extensive assessment (unexplained chronic cough; UCC). Many of these patients exhibit clinical features of cough hypersensitivity, including laryngeal paresthesia, hypertussia, and allotussia. Over-the-counter cough remedies are ineffective and can lead to intolerable side effects when used for RCC/UCC, and the lack of approved treatments indicated for these conditions reflects

SUBMITTER: Mazzone SB 

PROVIDER: S-EPMC7983941 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature