Tertiary Lymphoid Structure-B Cells Narrow Regulatory T Cells Impact in Lung Cancer Patients.

ABSTRACT: The presence of tertiary lymphoid structures (TLS) in the tumor microenvironment is associated with better clinical outcome in many cancers. In non-small cell lung cancer (NSCLC), we have previously showed that a high density of B cells within TLS (TLS-B cells) is positively correlated with tumor antigen-specific antibody responses and increased intratumor CD4⁺ T cell clonality. Here, we investigated the relationship between the presence of TLS-B cells and CD4⁺ T cell profile in NSCLC patients. The expression of immune-related genes and proteins on B cells and CD4⁺ T cells was analyzed according to their relationship to TLS-B density in a prospective cohort of 56 NSCLC patients. We observed that tumor-infiltrating T cells showed marked differences according

SUBMITTER: Germain C 

PROVIDER: S-EPMC7983944 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature