Acute cigarette smoke-induced eQTL affects formyl peptide receptor expression and lung function.

ABSTRACT:

Background and objective

Cigarette smoking is one of the most prevalent causes of preventable deaths worldwide, leading to chronic diseases, including chronic obstructive pulmonary disease (COPD). Cigarette smoke is known to induce significant transcriptional modifications throughout the respiratory tract. However, it is largely unknown how genetic profiles influence the smoking-related transcriptional changes and how changes in gene expression translate into altered alveolar epithelial repair responses.

Methods

We performed a candidate-based acute cigarette smoke-induced eQTL study, investigating the association between SNP and differential gene expression of FPR family members in bronchial epithelial cells isolated 24 h after smoking and after 48 h without smoking. The eff

SUBMITTER: Pouwels SD 

PROVIDER: S-EPMC7983955 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature