The impact of body weight trajectory from childhood on chronic inflammation in adulthood: The Bogalusa Heart Study.

ABSTRACT:

Importance

The impact of long-term burden of excessive body weight, beginning in childhood, on inflammatory status in adulthood has been poorly described.

Objective

To characterize the longitudinal body mass index (BMI) trajectory from childhood and examine its relationship with inflammatory status in adulthood.

Methods

We included 1285 adults who had 4-15 repeat measurements of BMI from childhood to adulthood. The area under the curve (AUC) of growth curves was calculated to characterize long-term burden (total AUC) and trends (incremental AUC) of BMI.

Results

After adjusting for covariates, higher values of BMI in terms of childhood and adulthood, as well as total and incremental AUC, were strongly associated with elevated levels of adult C-reactive protein (

SUBMITTER: Yan Y 

PROVIDER: S-EPMC7984006 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature