Blood neuro-exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage.

ABSTRACT:

Introduction

Exosomes are an emerging candidate for biomarkers of Alzheimer's disease (AD). This study investigated whether exosomal synaptic proteins can predict AD at the asymptomatic stage.

Methods

We conducted a two-stage-sectional study (discovery stage: AD, 28; amnestic mild cognitive impairment [aMCI], 25; controls, 29; validation stage: AD, 73; aMCI, 71; controls, 72), a study including preclinical AD (160) and controls (160), and a confirmation study in familial AD (mutation carriers: 59; non-mutation carriers: 62).

Results

The concentrations of growth associated protein 43 (GAP43), neurogranin, synaptosome associated protein 25 (SNAP25), and synaptotagmin 1 were lower in AD than in controls (P < .001). Exosomal biomarker levels were correlated with those in

SUBMITTER: Jia L 

PROVIDER: S-EPMC7984076 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature