Extracellular vesicle biomarkers of Alzheimer's disease associated with sub-clinical cognitive decline in late middle age.

ABSTRACT:

Introduction

Neuronal extracellular vesicle (nEV) tau and insulin signaling biomarkers may detect preclinical Alzheimer's disease and age-associated cognitive decline.

Methods

This case-control study used repeated serum samples from 73 cognitively declining and 73 stable Wisconsin Registry for Alzheimer's Prevention participants (62.4 ± 6.3 years old). We immunocaptured nEVs; measured tau and insulin signaling biomarkers; and examined biomarker differences by group, their performance in group classification in training and test datasets (97, 49 individuals, respectively), and whether they predict cognitive performance change.

Results

Declining compared to stable individuals showed higher baseline total, p231-, and p181-tau with older age and higher annualized change f

SUBMITTER: Eren E 

PROVIDER: S-EPMC7984100 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature