Circulating metabolites are associated with brain atrophy and white matter hyperintensities.

ABSTRACT:

Introduction

Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH).

Methods

We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures.

Results

Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH.

Discussion

Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels

SUBMITTER: de Leeuw FA 

PROVIDER: S-EPMC7984157 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature