Modulation of cortical slow oscillatory rhythm by GABA_B receptors: an in vitro experimental and computational study.

ABSTRACT:

Key points

We confirm that GABA_B receptors (GABA_B -Rs) are involved in the termination of Up-states; their blockade consistently elongates Up-states. GABA_B -Rs also modulate Down-states and the oscillatory cycle, thus having an impact on slow oscillation rhythm and its regularity. The most frequent effect of GABA_B -R blockade is elongation of Down-states and subsequent decrease of oscillatory frequency, with an increased regularity. In a quarter of cases, GABA_B -R blockade shortened Down-states and increased oscillatory frequency, changes that are independent of firing rates in Up-states. Our computer model provides mechanisms for the experimentally observed dynamics following blockade of GABA_B -Rs, for Up/Down durat

SUBMITTER: Perez-Zabalza M 

PROVIDER: S-EPMC7984206 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature