Integrative transcriptome analysis deciphers mechanisms of nickel contact dermatitis.

ABSTRACT:

Background

Nickel-induced allergic contact dermatitis (nACD) remains a major occupational skin disorder, significantly impacting the quality of life of suffering patients. Complex cellular compositional changes and associated immunological pathways are partly resolved in humans; thus, the impact of nACD on human skin needs to be further elucidated.

Methods

To decipher involved immunological players and pathways, human skin biopsies were taken at 0, 2, 48, and 96 hours after nickel patch test in six nickel-allergic patients. Gene expression profiles were analyzed via microarray.

Results

Leukocyte deconvolution of nACD-affected skin identified major leukocyte compositional changes at 48 and 96 hours, including natural killer (NK) cells, macrophage polarization, and T-ce

SUBMITTER: Wisgrill L 

PROVIDER: S-EPMC7984291 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature