Controlling for selective dropout in longitudinal dementia data: Application to the SveDem registry.

ABSTRACT:

Introduction

Loss to follow-up in dementia studies is common and related to cognition, which worsens over time. We aimed to (1) describe dropout and missing cognitive data in the Swedish dementia registry, SveDem; (2) identify factors associated with dropout; and (3) estimate propensity scores and use them to adjust for dropout.

Methods

Longitudinal cognitive data were obtained from 53,880 persons from the SveDem national quality dementia registry. Inverse probability of censoring weights (IPCWs) were estimated using a logistic regression model on dropout.

Results

The mean annualized rate of change in Mini-Mental State Examination (MMSE) in those with a low MMSE (0 to 10) was likely underestimated in the complete case analysis (+1.5 points/year) versus the IPCW analys

SUBMITTER: Handels R 

PROVIDER: S-EPMC7984348 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature