Antibody kinetics and clinical course of COVID-19 a prospective observational study.

ABSTRACT:

Background

Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19.

Materials and methods

A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed.

Results

Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with se

SUBMITTER: Blackberg A 

PROVIDER: S-EPMC7984607 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature