Insights into the molecular basis of tick-borne encephalitis from multiplatform metabolomics.

ABSTRACT:

Background

Tick-borne encephalitis virus (TBEV) is the most prevalent arbovirus, with a tentative estimate of 10,000 to 10,500 infections occurring in Europe and Asia every year. Endemic in Northeast China, tick-borne encephalitis (TBE) is emerging as a major threat to public health, local economies and tourism. The complicated array of host physiological changes has hampered elucidation of the molecular mechanisms underlying the pathogenesis of this disease.

Methodology/principle findings

System-level characterization of the serum metabolome and lipidome of adult TBEV patients and a healthy control group was performed using liquid chromatography tandem mass spectrometry. By tracking metabolic and lipid changes during disease progression, crucial physiological changes that c

SUBMITTER: Du Y 

PROVIDER: S-EPMC7984639 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature