Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework.

ABSTRACT: The potential existence and roles of the meningeal lymphatic system in normal and pathological brain function have been a long-standing enigma. Recent evidence suggests that meningeal lymphatic vessels are present in both the mouse and human brain; in mice, they seem to play a role in clearing toxic amyloid-beta peptides, which have been connected with Alzheimer disease (AD). Here, we review the evidence linking the meningeal lymphatic system with human AD. Novel findings suggest that the recently described meningeal lymphatic vessels could be linked to, and possibly drain, the efferent paravascular glial lymphatic (glymphatic) system carrying cerebrospinal fluid, after solute and immune cell exchange with brain interstitial fluid. In so doing, the glymphatic system could contribute to the

SUBMITTER: Mentis AA 

PROVIDER: S-EPMC7985019 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature