Epigenome-wide analysis identifies genes and pathways linked to acoustic cry variation in preterm infants.

ABSTRACT:

Background

Preterm birth places infants at higher risk of adverse long-term behavioral and cognitive outcomes. Combining biobehavioral measures and molecular biomarkers may improve tools to predict the risk of long-term developmental delays.

Methods

The Neonatal Neurobehavior and Outcomes in Very Preterm Infants study was conducted at nine neonatal intensive care units between April 2014 and June 2016. Cries were recorded and buccal swabs collected during the neurobehavioral exam. Cry episodes were extracted and analyzed using a computer system and the data were summarized using factor analysis. Genomic DNA was extracted from buccal swabs, quantified using the Qubit Fluorometer, and aliquoted into standardized concentrations. DNA methylation was measured with the Illumina Me

SUBMITTER: Aghagoli G 

PROVIDER: S-EPMC7985041 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature