Potential Impact of DPYD Variation on Fluoropyrimidine Drug Response in sub-Saharan African Populations.

ABSTRACT: Cancer is a critical health burden in Africa, and mortality rates are rising rapidly. Treatments are expensive and often cause adverse drug reactions (ADRs). Fluoropyrimidine treatments can lead to severe toxicity events which have been linked to variants within the dihydropyrimidine dehydrogenase (DPYD) gene. There are clinical guidelines to improve safety outcomes of treatment, but these are primarily based on variants assessed in non-African populations. Whole genome sequencing data from the 1000 Genomes Project and the African Genome Variation Project were mined to assess variation in DPYD in eight sub-Saharan African populations. Variant functional annotation was performed with a series of bioinformatics tools to assess potential likelihood of deleterious impact. There w

SUBMITTER: da Rocha JEB 

PROVIDER: S-EPMC7985174 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature