Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ.

ABSTRACT: Although ductal carcinoma in situ (DCIS) is a non-obligate precursor to ipsilateral invasive breast cancer (iIBC), most DCIS lesions remain indolent. Hence, overdiagnosis and overtreatment of DCIS is a major concern. There is an urgent need for prognostic markers that can distinguish harmless from potentially hazardous DCIS. We hypothesised that features of the breast adipose tissue may be associated with risk of subsequent iIBC. We performed a case-control study nested in a population-based DCIS cohort, consisting of 2658 women diagnosed with primary DCIS between 1989 and 2005, uniformly treated with breast conserving surgery (BCS) alone. We assessed breast adipose features with digital pathology (HALO^®, Indica Labs) and related these to iIBC risk in 108 women that developed su

SUBMITTER: Almekinders MMM 

PROVIDER: S-EPMC7985299 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature