Ontology highlight
ABSTRACT:
SUBMITTER: Hossian AKMN
PROVIDER: S-EPMC7985311 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Hossian A K M Nawshad AKMN Zahra Fatema Tuz FT Poudel Sagun S Abshire Camille F CF Polk Paula P Garai Jone J Zabaleta Jovanny J Mikelis Constantinos M CM Mattheolabakis George G
Scientific reports 20210322 1
This study aims to identify pathway involvement in the development of cisplatin (cis-diamminedichloroplatinum (II); CDDP) resistance in A549 lung cancer (LC) cells by utilizing advanced bioinformatics software. We developed CDDP-resistant A549 (A549/DDP) cells through prolonged incubation with the drug and performed RNA-seq on RNA extracts to determine differential mRNA and miRNA expression between A549/DDP and A549 cells. We analyzed the gene dysregulation with Ingenuity Pathway Analysis (IPA; ...[more]